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ResMed AirSense 10 AutoSet Card to Cloud CPAP Machine

Ideal For:

  1. New CPAP users looking for smart features to help them adjust to therapy
  2. Those with nasal congestion or allergies
  3. People who have trouble exhaling against higher pressure levels


  1. May not be necessary if standard CPAP therapy doesn’t negatively affect your breathing
  2. Not suitable if you’ve been prescribed BiPAP therapy by your doctor
  3. The LCD screen’s brightness can’t be adjusted manually

Sleep Foundation Special Offer

Use this link for the most current ResMed discount

ResMed offers a wide range of positive airway pressure (PAP) devices, including continuous positive airway pressure (CPAP), automatic positive airway pressure (APAP), bilevel positive airway pressure (BiPAP), and travel machines. The California-based medical equipment company also makes PAP accessories like masks, air filters, humidifiers, and hoses. 

The AirSense 10 series includes two CPAP machines and two APAP models. The AirSense 10 CPAP and Elite are fixed-pressure machines, so they deliver continuous air pressure throughout the night. The AutoSet and AutoSet for Her are APAP models that automatically adjust air pressure levels according to the user’s breathing patterns.

We’ll focus on the ResMed AirSense 10 AutoSet. It offers a number of advanced features, such as a ramp setting that detects sleep onset, a function that lowers the air pressure when you exhale, and an algorithm that can detect more complex breathing conditions like central sleep apnea and Cheyne-Stokes respirations.

ResMed AirSense 10 Video Review

Watch our video below to get an in-depth look at the ResMed AirSense 10. We explore how the machine works and how it compares to other CPAP devices.

ResMed AirSense 10 AutoSet CPAP Machine Review Breakdown

The ResMed AirSense 10 AutoSet delivers pressurized air through a tube and mask. The device comes with heated ClimateLineAir tubing, but a CPAP mask needs to be purchased separately.

AutoSet is ResMed’s trademarked term for its APAP technology. While the AirSense 10 AutoSet also has a standard CPAP function, the AutoSet algorithm detects breathing patterns and automatically adjusts air pressure within your prescribed pressure range.

A built-in HumidAir humidifier moisturizes the air to help reduce dry nasal passages. The humidifier works with ResMed’s ClimateLineAir heated tubing, which is also included with your purchase. 

The SmartStart feature automatically begins therapy as soon as you put your mask on and stops when you remove it. The AutoRamp function slowly raises air pressure to your prescribed levels and can also sense when you’ve fallen asleep. ResMed’s Expiratory Pressure Relief feature automatically lowers pressure levels during exhalation to make breathing more comfortable.

What’s Included

The AirSense 10 AutoSet is a compact machine with a built-in humidifier and detachable water chamber. A hose elbow connects the tubing to the machine at a right angle, giving the pressurized air a clear pathway. The machine comes with a pre-installed filter and a travel bag. 

PAP TypeComponents
  • AirSense 10 AutoSet device
  • ClimateLineAir heated tubing
  • Built-in humidifier
  • Water chamber
  • Air filter and filter cover
  • Travel bag

Product Features

The AirSense 10 AutoSet CPAP Machine has a number of features to customize therapy and enhance comfort. A color LCD screen has intuitive prompts to help users adjust settings and track therapy compliance and other sleep data. The screen’s brightness automatically dims when the room goes dark. 

The AutoRamp feature with sleep onset detection begins therapy at a lower pressure level and gradually increases to your prescribed level once you’ve fallen asleep.

Since breathing against high pressure settings can be challenging for some people, the machine’s Expiratory Pressure Relief feature lowers air pressure when the user exhales. You can run a mask fit test prior to therapy to detect leaks in the mask or hose.


  • SmartStart: Therapy automatically begins as soon as you breathe into your mask and ceases when you remove your mask. You can also manually start and stop therapy.
  • ClimateLineAir: The AirSense 10 AutoSet’s built-in humidifier can be paired with ResMed’s ClimateLineAir heated tubing to regulate air temperature and humidity levels. Increasing air moisture may alleviate nosebleeds, sore throats, and other symptoms related to dry breathing passages.
  • AutoSet: This APAP algorithm determines the lowest pressure level needed to keep your airways open. Pressure levels increase within a prescribed range based on your unique breathing patterns.
  • AutoRamp: The machine delivers a lower pressure level as you fall asleep and then gradually increases pressure to your prescribed level. This makes falling asleep feel more natural.
  • Expiratory Pressure Relief: The EPR function automatically lowers air pressure during exhalation to make breathing more comfortable.

Sizing and Pricing

With the humidifier tank attached, the ResMed AirSense 10 AutoSet measures about 10 inches across and 4.6 inches tall, with a depth just under 6 inches. The machine weighs approximately 2.75 pounds. The compact and lightweight design fits easily on most nightstands.

Size Comparison:

  • Travel: While the AirSense 10 AutoSet is larger than a travel CPAP machine, it’s still a relatively travel-friendly size. The device is approved by the Federal Aviation Administration for use on a plane.
  • Standard: This ResMed device is somewhat smaller and lighter than the average PAP machine. The humidifier doesn’t add notable bulk, so the entire machine shouldn’t take up too much space on your nightstand or table. 

The AirSense 10 AutoSet costs slightly below the average APAP machine price, which typically range from $450 to $1,800. It has a built-in humidifier and multiple comfort features that many less expensive models lack.

ResMed AirSense 10 AutoSet Connected with HumidAir and ClimateLineAir

10″ x  5.9″ x 4.6″ (machine only)2.75 lbs. (machine only)$1,164

Device Performance

  • Sound Level: The average CPAP machine has a sound pressure level of 30 decibels. The AirSense 10 AutoSet’s sound output is about 27 decibels, which is considered whisper-quiet.
  • Ease of Use: The LCD screen has a straightforward menu that helps users adjust settings with a simple dial. Easy-to-read icons track therapy progress and compliance. The Mask Fit feature displays a smiling emoji to show that your mask fits properly and isn’t leaking. A similar icon appears when the humidifier is working properly.
  • Portability: The AirSense 10 AutoSet’s relatively compact size makes it suitable for travel. You can reduce bulk even more by removing the water chamber.
  • Pressure Settings: The device’s pressure range is 4 to 20 centimeters of water pressure (cm H2O), which is typical of most CPAP machines. Pressure levels can be calibrated by 0.2 cm H2O increments. Speak with your doctor if your prescribed pressure range causes discomfort or is no longer effective.
  • Air Temperature and Humidity controls: The HumidAir humidifier has a climate control feature that automatically adjusts air temperature and relative humidity to optimal levels. Users can also manually adjust the temperature and humidity levels of the ClimateLineAir tubing.
  • Compatibility: The AirSense 10 AutoSet is compatible with most CPAP masks regardless of the manufacturer. This includes different types like nasal masks, nasal pillows, and full-face masks.
  • Maintenance: ResMed recommends washing the humidifier basin daily and the hosing on a weekly basis. Both components should be cleaned with warm water and mild soap, then air-dried on a towel. Avoid drying in direct sunlight.

    The water tank should also be soaked weekly for 15 to 20 minutes in a solution that’s equal parts white vinegar and water. Once soaked, it should be rinsed with warm water and air-dried on a flat surface.
    Consult your mask manufacturer’s cleaning recommendations. Generally, mask components should be wiped daily and washed weekly with warm soapy water.

Sleep Foundation Special Offer

Use this link for the most current ResMed discount

Trial, Warranty, and Shipping Policies


The ResMed AirSense 10 AutoSet CPAP Machine can be purchased through authorized online CPAP retailers. The machine is also sold at select medical equipment stores.


Shipping locations and timelines vary according to the seller. Many online retailers offer free shipping for customers in the contiguous U.S. Some companies ship to all 50 states. 

The AirSense 10 AutoSet consists of just a few main parts, so it’s relatively straightforward to assemble. Instructions are outlined in the user manual. ResMed also has a video tutorial on its website to help new users set up the machine.

Sleep Trial

Given that CPAP machines are considered medical equipment, most companies only accept returns on new and unused machines.


The AirSense 10 AutoSet device and humidifier are backed by a two-year manufacturer’s warranty. Other components have separate warranty policies. The ClimateLineAir hose is covered for 90 days. The humidifier’s water chamber is covered for one year.

Still have questions?

Our product experts have extensive experience testing just about every sleep product on the market. Send an email to [email protected] or call us at (877) 672-8966 with your questions and we’ll help you find exactly what you’re looking for.

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