About 22% of people experience dry mouth, also called xerostomia. Dry mouth can feel uncomfortable and negatively affect a person’s quality of life. If your mouth becomes dry at night, it might also disrupt your sleep, causing you to wake up.

We examine the symptoms, risk factors, preventative measures, and treatments for dry mouth, and discuss when it may be appropriate to talk to a doctor.

What Is Dry Mouth?

Dry mouth is the subjective sensation of having a mouth that feels dry. This condition overlaps with but differs from hyposalivation, in which a person’s glands produce too little saliva. Hyposalivation is objectively defined by measuring a person’s saliva output, while dry mouth is self-reported according to how a person’s mouth feels to them.


The primary symptom of xerostomia is having a dry sensation in your mouth. Doctors determine if a person has dry mouth by asking a series of questions about how their mouth feels at different times.

Many doctors and researchers use a list of symptoms called the xerostomia inventory, or a shortened version of this list. For example, medical professionals may ask questions regarding the severity of:

  • How dry your mouth feels when eating
  • How difficult it is to eat dry foods
  • How dry your lips feel
  • How dry your mouth feels at night or on awakening
  • How thirsty you feel at night

Although having a mouth that feels dry is the primary criteria, other symptoms often accompany xerostomia. The American Dental Association considers these symptoms to be complications or signs of dry mouth:

  • Bad breath
  • A burning sensation or sores in the mouth
  • Difficulty chewing, swallowing, or speaking
  • A change in taste or difficulty tolerating spicy, salty, or sour flavors
  • Dry and cracked lips
  • A rough tongue
  • Infections in the mouth
  • Trouble keeping in dentures

Chronic dry mouth can also contribute to tooth decay, plaque, eroded enamel, or tooth demineralization in the form of white spots, as well as sensitive teeth and inflamed gums.

Causes and Risk Factors

Multiple factors can cause a person to experience dry mouth, whether during the day or at night. Identifying the cause of your dry mouth may help you figure out how to treat it and prevent it from recurring.


If you find yourself waking up thirsty during the night or experiencing dry mouth when you wake up, you might be dehydrated. Dehydration occurs when you consume less water than your body expels, whether through urine, sweat, or other means.

Dehydration is more likely to occur when you are not drinking much water or when you are losing more fluids than usual. For example, having diarrhea or sweating due to exercise or warm weather can cause you to lose more fluids. In some cases, underlying medical issues, such as diabetes, can contribute to dehydration.

Mouth Breathing

Breathing through your mouth instead of your nose as you sleep can cause dry mouth at night. Nighttime mouth breathing can result from blocked nasal passages and is associated with sleep-disordered breathing. Working with a doctor or sleep specialist can uncover why a person breathes through their mouth at night and how to treat it.

Medications and Medical Treatments

A variety of medications can cause dry mouth as a side effect, in part because many medications interfere with saliva production. Being on more than one medication may also increase a person’s risk of dry mouth. Some medications that might lead to dry mouth include:

  • Antihistamines
  • Decongestants
  • Antidepressants
  • Antipsychotics
  • Some muscle relaxants
  • Diuretics
  • Certain stimulants used to treat attention deficit hyperactivity disorder (ADHD)
  • Bladder medications that reduce urination
  • Some sedatives
  • Some medications used to treat glaucoma, dementia, or Parkinson’s disease
  • Certain asthma medications

Dry mouth can also result from certain medical treatments. Radiation of the head and neck as part of a cancer treatment is commonly associated with dry mouth. Continuous positive airway pressure (CPAP) machine use, a treatment for obstructive sleep apnea, has also been associated with dry mouth.


Sometimes dry mouth occurs as a symptom of, or along with, another physical health issue.

Dry mouth is one of the primary symptoms of Sjögren syndrome , an autoimmune disorder. Doctors often measure saliva output and check for abnormalities in saliva glands when diagnosing Sjögren syndrome. In addition to dry mouth, Sjögren syndrome often causes dry eyes. Less commonly, dryness may occur in other parts of the body.

Other illnesses and medical conditions can also cause dry mouth. Some of these illnesses include:

  • Obstructive sleep apnea
  • Diabetes 
  • Coronavirus disease 2019 (COVID-19)
  • Human immunodeficiency virus infection (HIV)
  • High blood pressure
  • Hepatitis C


Dry mouth is more common in older adults. This may be due to increased use of medications that cause dry mouth.


Toxins in cigarette smoke lead cigarette smokers to produce less saliva than non-smokers, which can result in more instances of dry mouth over time.

Biological Sex

Several studies have found that dry mouth is more prevalent in women . This prevalence is independent of medication use, meaning that it is not due to women taking more medications. More research is needed to better understand this association.


There are several home remedies you can try to prevent dry mouth at night if you are at risk.

Drink Plenty of Fluids

If your dry mouth is mainly due to dehydration, drinking plenty of fluids might help reduce discomfort. In addition to drinking water throughout the day, consider keeping a glass of water next to your bed at night. You may also be able to stimulate saliva production before bed by chewing sugar-free gum or using a non-alcoholic mouthwash.

Use a Humidifier

Dry mouth may worsen when you are in a space with low humidity. Use a humidifier at night to keep your bedroom air from becoming too dry.

Quit Smoking

Smokers tend to produce less saliva, so quitting smoking could reduce your chances of experiencing dry mouth at night.

Address Mouth Breathing

If you breathe through your mouth at night due to a blocked nose or CPAP therapy, you may be able to reduce dry mouth by treating your nasal congestion or making adjustments to your CPAP setup, such as adding a humidifier to your device, in consultation with your doctor.

Review Medications

Check any prescription drugs, supplements, or over-the-counter medications you are taking to see if dry mouth, or xerostomia, is listed as a potential side effect. If dry mouth is a side effect of a medication you take, do not stop taking it right away. Instead, make an appointment with your doctor. They can determine if you can safely reduce your medication dosage, discontinue the medication, or change your medication schedule in order to reduce mouth dryness at night.


Multiple strategies exist for treating dry mouth, depending on the root cause.

Artificial Saliva

Research demonstrates that saliva substitutes may relieve dry mouth in people who cannot find relief through other methods. Saliva substitutes, or artificial saliva, are lubricants that generally take the form of a gel or mouthwash. Some types of artificial saliva work better than others, so it may be helpful to consult a doctor who is familiar with the differences across types.


The U.S. Food and Drug Administration (FDA) has approved two salivary stimulants designed for treating dry mouth for people with certain medical conditions. Some evidence also suggests that amifostine , a medication often prescribed to reduce side effects of chemotherapy, can reduce the dry mouth associated with radiation therapy. These medications may come with their own side effects, and you should consult your doctor before starting any new medication.


Some health professionals believe that acupuncture might be able to help treat dry mouth by stimulating saliva production, though more research is needed to confirm this theory.

When to Talk to Your Doctor

Not all people who experience dry mouth at night need to see a doctor. Sometimes home remedies like drinking more water, using a bedroom humidifier, or quitting smoking might solve the problem.

Consider making an appointment with your primary care physician if:

  • Home treatments do not alleviate your symptoms
  • Dry mouth is affecting your sleep
  • Your dry mouth is accompanied by other symptoms such as dry eyes or enlarged salivary glands

Your doctor can review the medications you take or order tests to determine if your dry mouth is due to an underlying disorder.

People who frequently experience dry mouth may need to pay extra attention to dental care and visit their dentist more often to prevent damage to their teeth. The American Dental Association suggests using topical fluoride to reduce the risk of cavities. Your doctor can also help you treat secondary infections arising due to dry mouth.

Medical Disclaimer: The content on this page should not be taken as medical advice or used as a recommendation for any specific treatment or medication. Always consult your doctor before taking a new medication or changing your current treatment.

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9 Sources

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