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Compare Sleep Aids

Eric Suni

Written by

Eric Suni, Staff Writer

Alex Dimitriu

Medically Reviewed by

Alex Dimitriu, Psychiatrist

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Sleep problems are commonplace in America with around 35% of adults failing to get the recommended amount of sleep per night. To try to get better rest, many people take sleep aids, which include prescription drugs, over-the-counter medications, and dietary supplements.

The CDC reports that more than 8% of adults say that they used a sleep aid multiple times in the previous week. With so many types of medications available, many people struggle to compare sleep aids and know which can best help them sleep.

Ultimately, every sleep aid offers potential benefits and poses certain risks. To help you better understand your options, we take an in-depth look at the different types of sleep aids and how they work. With this information, you can talk with your doctor to identify the best sleep aid in your case and ensure that you take it safely.

How Do You Pick the Best Sleep Aid For You?

Working closely with your doctor is the best way to compare and pick a sleep aid. A health care professional can recommend the best sleep medication for your situation, accounting for factors including:

  • The symptoms and cause of your sleep problems
  • Your age and overall health including other medical conditions
  • Other medications that you take

Whether you are considering prescription drugs, over-the-counter medications, or dietary supplements, your doctor can explain the potential benefits and risks and help make sure that you take the right dosage at the right time.

The American Academy of Sleep Medicine (AASM) is a medical society that organizes expert panels to help guide treatment for sleep problems. The AASM’s recommendations for sleep medications offer useful information about sleep aids for insomnia, but your doctor can best explain how those recommendations apply in your individual circumstances.

In some cases, the best sleep aid may not be a medicine at all. Non-drug treatments such as a type of counseling called cognitive behavioral therapy for insomnia (CBT-I) or a focus on sleep hygiene can often make it easier to get to sleep. These approaches may be combined with medications as part of a plan to get better sleep over the long-term without relying on sleep aids.

Prescription Sleep Aids for Insomnia

Prescription sleep medications are only available from a pharmacy, and to obtain them you must have a prescription from your doctor.

Insomnia occurs when a person cannot fall asleep or stay asleep even when they have the chance to do so. It is the most common sleep disorder, and many prescription sleep aids are designed to treat insomnia.

Several kinds of drugs may be used. While they are chemically different, they have many similar effects and potential side effects.

Z Drugs

Z drugs are a type of sedative-hypnotic medication that makes people feel sleepy. The drug names feature the letter Z, which is how they derive this informal name.

Specific Z Drugs Approved To Treat Insomnia: Zolpidem, eszopiclone, zaleplon

Indicated Usage: Z drugs are approved by the FDA for short-term therapy for insomnia. Some Z drugs can help with both getting to sleep and sleeping through the night, but others are only recommended by the AASM for help falling asleep.

Side Effects and Precautions

  • Daytime drowsiness: Some people report lingering effects on mental function that last into the next day. This may cause drowsiness or slowed thinking and can pose risks for activities like driving.
  • Cognitive impairment: In addition to making someone sleepy, Z drugs can cause loss of balance and reduced mental alertness, which may make someone prone to falls or other inadvertent injury.
  • Dependence: People can become addicted to Z drugs, leading them to take them for longer or at higher doses than indicated.
  • Withdrawal: Suddenly stopping taking Z drugs can cause withdrawal symptoms including worsened sleep as well as physical effects, impaired thinking, and mood changes.
  • Abnormal thinking and behavior: Some people engage in odd behavior while partially asleep after they have taken Z drugs. Some of these behaviors, such as trying to drive a car, can be dangerous.
  • Worsening of depression: Some people with depression find that their symptoms are worse when taking Z drugs.
  • Allergic reaction: These reactions are rare, but when they do occur, they can be serious and induce anaphylaxis.

Who Shouldn’t Use Z Drugs

When taken at the proper timing and dosage, Z drugs are safe for most people. Older adults who are at higher risk of falls should use caution before taking Z drugs.

Studies have found that women are frequently more affected than men by the same dose of these drugs, increasing the risks of next-day impairment. Anyone taking Z drugs should inform their doctor if they have any lasting effects of these drugs in the morning.

These sleep aids should not be combined with alcohol, opiates, or other pain medications. Generally, sedatives should not be combined. This can lead to worsening respiratory function.

Orexin Receptor Antagonists

Orexin receptor antagonists are a newer class of drugs that induce sleep by affecting the sleep-wake cycle. They accomplish this by decreasing production of orexin, a chemical in the brain that causes alertness.

Specific Orexin Receptor Antagonists Approved To Treat Insomnia: Suvorexant, lemborexant

Indicated Usage: Orexin receptor antagonists are approved by the FDA for the treatment of insomnia related to both sleep onset and sleep maintenance. The AASM, though, has not recommended these drugs for help with falling asleep.

When AASM recommendations were published in 2017, they did not mention lemborexant, which was not approved by the FDA until late 2019. Although the AASM does not have a recommendation for or against lemborexant, recent studies indicate that it may help with both sleep onset and sleep maintenance.

Side Effects and Precautions

  • Daytime drowsiness: The sleepiness from orexin receptor antagonists may persist until the next day, which can be problematic for operating a motor vehicle or heavy machinery.
  • Cognitive impairment: Dramatic reductions in alertness may affect balance or thinking, heightening the risk of accidental injuries and falls.
  • Dependence: Taking orexin receptor agonists can be habit-forming, and there is a risk of abuse of these medications.
  • Withdrawal: Insomnia symptoms may quickly return if you suddenly stop taking orexin receptor antagonists.
  • Abnormal thinking and behavior: Strange actions taken while partially asleep can occur after taking orexin receptor antagonists. These actions may be benign or dangerous, such as attempting to drive a car.
  • Worsening of depression: Some people who have mood disorders find that their symptoms can get worse with orexin receptor antagonists.
  • Allergic reaction: Very few people have allergies to these drugs, but an adverse response is possible.

Who Shouldn’t Use Orexin Receptor Antagonists

When taken for the prescribed length of time and at the right dosage, these drugs are typically safe for most adults. Older adults and people at risk of falls should take these sleep aids with caution.

Melatonin Receptor Agonist

A melatonin receptor agonist is a drug that increases the amount of melatonin in the body. Melatonin is a hormone that is naturally produced in response to darkness. Melatonin helps the body regulate its internal clock, also known as its circadian rhythm.

Specific Melatonin Receptor Agonists Approved To Treat Insomnia: Ramelteon

Indicated Usage: Ramelteon is approved by the FDA to treat insomnia related to initially falling asleep.

Side Effects and Precautions

Ramelteon is generally well tolerated. While it can cause some similar side effects, the risk is generally lower than with other prescription sleep medications.

  • Daytime drowsiness: The effects of ramelteon may last into the next day. Reduced alertness can elevate the risk of car crashes or other accidents.
  • Cognitive impairment: Thinking may be slowed after taking ramelteon. It can also affect coordination, potentially contributing to the risk of falls or other injuries.
  • Abnormal thinking and behavior: Although less common than in some other sleep medications, some people may engage in strange behavior, such as sleepwalking or trying to drive their car while partially asleep.
  • Worsening of depression: Certain people who have depression may find that their symptoms are worse with ramelteon.
  • Allergic reaction: Although uncommon, it is possible to have an acute allergic reaction to ramelteon.

Who Shouldn’t Use Melatonin Receptor Agonists

Most people can use ramelteon safely. It should not be used by people with sleep maintenance insomnia and should be used with caution in people who have other health conditions that could be affected by this drug.


Benzodiazepines are sedative-hypnotic drugs that work by slowing brain activity to help make a person feel sleepy. These drugs were among the earliest prescription medications for insomnia, but newer drugs are now more likely to be used as an initial therapy. Benzodiazepines may also be used for anxiety disorders and seizures.

Specific Benzodiazepines Approved To Treat Insomnia: Temazepam, triazolam, estazolam, quazepam, flurazepam

Indicated Usage: Benzodiazepines are approved for short-term use, generally lasting 7 to 10 days, to treat insomnia. The AASM recommends some benzodiazepines only to help fall asleep while others may help fall asleep and stay asleep.

Side Effects and Precautions

  • Breathing problems: Benzodiazepines can impair breathing and carry a special warning from the FDA about potentially life-threatening dangers when using these medications along with opioid drugs or alcohol.
  • Daytime drowsiness: Some people find that they are still groggy the day after taking benzodiazepines. These drugs can remain in someone’s system for many hours, which may lead to a lasting effect, especially at higher dosages. Daytime drowsiness may affect mental function and reaction time, posing particular risks for driving.
  • Cognitive impairment: Benzodiazepines can affect thinking and may make people feel dizzy or confused. This can raise the risk of accidents or falls.
  • Dependence: These drugs are habit-forming, which means that you can become addicted to them.
  • Withdrawal: When a person stops taking benzodiazepines, sleep problems may recur or get worse. Physical, cognitive, and emotional effects may arise if a person stops taking these drugs abruptly.
  • Abnormal thinking and behavior: Sedative-hypnotics like benzodiazepines can cause strange thoughts or behaviors, including hallucinations or complex behaviors like sleepwalking or trying to drive while partly asleep.
  • Worsening of depression: Some people may experience a worsening of symptoms of depression when taking benzodiazepines.
  • Allergic reaction: Though rare, some people have severe allergic reactions that can affect breathing.

Who Shouldn’t Use Benzodiazepines

Benzodiazepines are generally not recommended for older adults because of the risk of cognitive impairments that may lead to accidents or falls.

Because of their potential effect on breathing, benzodiazepines are less often used in people who have obstructive sleep apnea. Benzodiazepines should not be used by patients who are also taking opioid drugs.


Antidepressants treat the mood disorder depression. Because these medications can have a sedative effect, they have also been used as sleep aids.

Specific Antidepressants Approved To Treat Insomnia: Doxepin

Indicated Usage: Only one antidepressant has been approved by the FDA specifically for insomnia, and the AASM recommends its use only for helping people stay asleep through the night.

The AASM does not recommend any other antidepressants for off-label use in treating insomnia. A research review found that there is a lack of rigorous evidence about the safety and effectiveness of most antidepressants when used for treating sleeping problems.

Side Effects and Precautions

  • Suicidal thoughts: The FDA warns that some people younger than 24 who have taken doxepin or other antidepressants have had an increase in suicidal ideation.
  • Cognitive impairment: A decrease in alertness from antidepressants may hinder a person’s thinking and balance.
  • Abnormal thinking and behavior: Atypical behavior that occurs when partially asleep may occur when taking antidepressants for insomnia. These behaviors may even be life-threatening if they involve operating a car or engaging in other risky activity.
  • Effects on vision: Doxepin may alter pupil size, causing blurred vision. It may also heighten the risk of glaucoma.

Who Shouldn’t Use Antidepressants

Antidepressants like doxepin are often not recommended for older adults because of their effects on cognition and possible cardiovascular effects.


Antipsychotics are drugs that are meant to help people who have mental health disorders in which they struggle to know what is and is not real. It also used to treat bipolar disorder, which for many can present as cyclical insomnia.

Some antipsychotics have a sedative effect, but none have been approved by the FDA or recommended by the AASM for treating sleep problems. They may be most useful when prescribed for patients who have co-occurring mental health conditions and insomnia.


Anticonvulsants are designed to stop or reduce seizures or other unwanted muscle activity.

Although they can have a sedative effect, no anticonvulsants are FDA-approved for insomnia, and the AASM does not recommend their use. They must be prescribed off-label when given for sleeping problems.

Over-the-Counter Sleep Aids

Over-the-counter (OTC) sleep aids can be purchased in pharmacies and many other stores without a prescription. They must meet certain FDA standards, but they are not individually approved and regulated in the same way as prescription drugs.

OTC sleep aids are antihistamines, a type of allergy medication that commonly have a sedative effect. Two generic antihistamines are found in many brands of OTC sleep aids. These products may contain the antihistamine alone or in combination with other ingredients.

Specific over-the-counter sleep aids: Diphenhydramine, doxylamine

Indicated usage: Antihistamine sleep aids may be taken for short-term problems with falling or staying asleep. However, the AASM does not recommend the use of these drugs for insomnia.

The AASM’s recommendations do not specifically address doxylamine. A separate analysis of existing research concluded that there is limited evidence supporting OTC antihistamines as a treatment for insomnia.

Side Effects and Precautions

  • Daytime drowsiness: Antihistamines can cause some people to wake up groggy, which may impair their ability to carry out normal activities like driving. Some OTC sleep aids also have anticholinergic activity, which may be associated with an increased risk of cognitive impairment or accelerating dementia.
  • Cognitive impairment: Feeling foggy, dizzy, or mentally out-of-it can occur with these drugs, which may make them a contributor to the risk of injuries.  Confusion and loss of coordination may be especially worrisome for older adults.
  • Dependence: Some people become reliant on these drugs to sleep but build up a tolerance, leading them to continue increasing the dose that they take.
  • Withdrawal: Although serious withdrawal symptoms are not common, sleep problems may come back after stopping taking OTC sleep aids.
  • Dry mouth: Excessive dryness of the mouth, throat, or nose can occur with antihistamines.
  • Chest Congestion: Taking OTC sleep aids may lead to an increase in chest congestion.
  • Allergic reaction: In rare cases, people may have allergic reactions that require medical attention.
  • Accidental overdose: Patients should read labels carefully to avoid double-dosing by taking an OTC sleep aid and a cold, flu, or allergy medication that also has an antihistamine.

Who Shouldn’t Use Over-the-Counter Sleep Aids

Older people should be cautious about taking OTC sleep aids because of their detrimental effects on coordination and concentration. People with coexisting health conditions should be aware of the effects of antihistamines and talk with a pharmacist or doctor about possible adverse reactions.

Dietary Supplements

Dietary supplements do not require a prescription and are widely available in drug stores, supermarkets, and health stores.

Supplements with melatonin or valerian root are among the most popular sleep remedies, but many other products, including many natural sleep aids, are available from different brands.

Indicated Usage: The intended use should be described on each product along with a list of the ingredients and recommended dosage. In most cases, dietary supplement sleep aids are meant to be taken before bed to assist with falling or staying asleep.

In reviewing available evidence, the American Academy of Sleep Medicine chose not to recommend melatonin or valerian as treatments for insomnia. The AASM found too little data about other natural sleep aids or dietary supplements to make a recommendation.

Reputable Sleep Supplements
The safety and efficacy of supplements is not closely monitored by the U.S. Food and Drug Administration (FDA). Shoppers should take additional measures to make sure they are purchasing reputable products.

Side Effects and Precautions

As with any sleep aid, there can be unwanted adverse effects when taking natural sleep aids or dietary supplements.

  • Daytime drowsiness: The drowsiness from a sleep aid may last longer than intended, making a person continue feeling sleepy into the next day.
  • Cognitive impairment: The sedative effect of some dietary supplements can cause loss of concentration or balance.
  • Drug Interactions: Dietary supplements may interact with other medications including by increasing or decreasing their potency.
  • Tainted Products: The FDA has warned the public of an uptick in cases of dietary supplement sleep aids that are laced with other compounds, including traces of some prescription drugs.
  • Inaccurate Dose Labeling: A study found that over 70% of melatonin supplements had significant discrepancies between the dosage on the label and the actual dose in the product. This may impact the effectiveness of the product and raise the risk of taking too large of a dose.

Who Shouldn’t Use Dietary Supplements

It is often safe for adults to take natural sleep aids and other dietary supplements under the guidance of a doctor. However, because many of these products have not been extensively tested, their effects may be unpredictable.

Older adults should be cautious because of the potentially strong sedative effects of some sleep aids as well as the potential to interact with other medications.

Sleep Aids for Children and Pregnant People

Pregnant people should talk with their doctor before taking any sleep aid, including dietary supplements like natural sleep aids. Some sleep medications can have harmful effects during pregnancy for either a woman or their baby. Those who are breastfeeding should also consult with a doctor before taking any sleep aid.

Parents should use caution before giving their child any kind of sleep aid. Most sleep medications are tested primarily in adults, and their safety and effectiveness in children may be unclear. A pediatrician can offer the most tailored advice about the optimal sleep aid for a child’s situation.

How Much Do Sleep Aids Cost?

The cost of sleep aids can vary considerably. For prescription medication, the cost depends on a person’s health insurance coverage and whether a generic version of the drug is available.

The price of over-the-counter medications and dietary supplements depends on the brand, formulation, and where they are purchased. Shoppers can frequently compare prices online or in different stores.

Taking Sleep Aids Safely

No matter what kind of sleep aid you use, it is important to take precautions.

  • Take the right dose: Only take the prescribed dose at the recommended time. Even if you still struggle to sleep, do not take another dose during the night unless advised to do so by your doctor.
  • Improve sleep hygiene: Focus on sleep hygiene in conjunction with any sleep aids.
  • Get a full night’s rest: Make sure you have at least seven to eight hours to sleep after taking a sleep aid in order to reduce the risk of morning grogginess.
  • Plan for short-term use: The risks from sleep medications may increase if they are taken for longer than recommended.
  • Do not mix sleep aids with other substances: Serious problems may arise if sedative sleep aids are mixed with alcohol, other sedatives, or recreational drugs.
  • Take sleep aids under the guidance of your doctor: Working with your doctor can prevent unwanted side effects or drug interactions that could affect your health.
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About Our Editorial Team

Eric Suni

Staff Writer

Eric Suni has over a decade of experience as a science writer and was previously an information specialist for the National Cancer Institute.

Alex Dimitriu



Dr. Dimitriu is the founder of Menlo Park Psychiatry and Sleep Medicine. He is board-certified in psychiatry as well as sleep medicine.


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