Medical Disclaimer: The content on this page should not be taken as medical advice or used as a recommendation for any specific medication. Always consult your doctor before taking any new medication or changing your current dosage.
More than one-third of American adults struggle to get enough sleep, and in response, many turn to sleeping pills. According to data from the CDC, 8.2% of American adults report using a sleep aid at least four times in the last week.
Sleep aids include prescription medications, over-the-counter drugs, and dietary supplements, many of which are labeled as “natural” sleep aids. Within those categories are multiple types of drugs and compounds that affect the body in distinct ways.
Every sleep aid has potential benefits and risks, so it’s important to be informed about how they work, what conditions they may help with, and how to use them safely. To find the best sleep medication, it’s necessary to work with a doctor who can recommend a specific sleep aid based on your situation.
There are three broad categories of sleep aids: prescription drugs, over-the-counter medications, and dietary supplements.
The categories are distinct based on the active ingredients they include and how they function. Each category is also subject to different types of regulation and accessibility.
Every drug approved by the FDA has a specific indication, which describes the medical conditions that it is intended to treat. However, once a drug is approved for one indication, doctors may prescribe it for other conditions, which is known as “off-label” use.
Many prescription drugs are approved by the FDA to treat sleep problems while others are used off-label to try to improve sleep. Groups like the American Academy of Sleep Medicine (AASM) work to create guidelines for health professionals about the pros and cons of these medications.
Prescription sleep medications generally work by altering chemicals in the brain that are involved in regulating sleep and wakefulness. The effects of the medication depend on which chemicals are affected.
The following sections describe some types of prescription medications that may be used for sleep problems.
Hypnotics and sedatives are drugs that are designed to make a person feel sleepy. The first generation of prescription hypnotics for sleeping problems were benzodiazepines. These drugs work by increasing the brain’s production of gamma-aminobutyric acid (GABA), a chemical that induces drowsiness.
In recent years, a newer class of hypnotics, often called Z-drugs based on their medical names, have become more commonly prescribed. These drugs also increase GABA production but in a modified way that generally has been found to have fewer side effects than traditional benzodiazepines.
Most hypnotic drugs can be formulated to be fast-acting or gradual-release to address whether a person has greater difficulty falling asleep or staying asleep.
Other types of sedative drugs, such as barbiturates, may help people feel sleepy, but they are rarely the first choice when treating sleeping problems due to the risk of addiction and overdose.
Orexin receptor antagonists work by blocking the effect of orexin, a natural substance that increases wakefulness. By decreasing levels of orexin, these drugs promote sleepiness without some of the effects that arise with other hypnotics like headache, nausea, and short-term forgetfulness.
Melatonin is a hormone that is naturally produced by the body that facilitates sleep and a steady circadian rhythm. A melatonin receptor agonist is a prescription drug that mimics the effect of melatonin and is typically used to help people who have problems getting to sleep. This prescription drug is different from an over-the-counter melatonin supplement.
Antidepressants are drugs that were initially developed to treat depression. Some of these drugs, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been found to cause drowsiness for some people. As a result, antidepressants are sometimes prescribed for sleeping problems.
Antidepressants have not been specifically approved by the FDA for sleeping problems, so this is an example of off-label use. That said, many people with depression also have sleeping problems, and these drugs may be prescribed to address their symptoms.
Anticonvulsants are drugs that are used primarily to treat seizures, and in some cases, they are prescribed off-label for sleeping problems. Their effect on sleep is tied to their potential anti-anxiety properties, but in-depth research is limited about their benefits for sleep.
Antipsychotics are a class of drugs used with mental health disorders as they work to reduce delusions and hallucinations. They are sometimes prescribed off-label as a treatment for sleeping problems because of their sedative effect that is tied to how they influence the chemical serotonin in the brain.
Over-the-counter (OTC) drugs can be purchased without a prescription and are frequently sold in pharmacies, drug stores, and many supermarkets. Individual brands of OTC medications do not require direct FDA approval, but the active ingredient in them must be FDA approved and they must meet specific standards set by the FDA.
There are many different brands of over-the-counter sleep medications. Almost all of these are antihistamines, which are commonly used to treat allergies. Antihistamines frequently cause drowsiness, which has led to their use as an OTC sleep aid.
A wide range of sleep aids are sold as dietary supplements. Dietary supplements do not require FDA approval before being sold and are not regulated in the same way as prescription and OTC drugs.
No prescription is required to purchase dietary supplements, and they are sold in pharmacies, drug stores, supermarkets, specialty stores, and online.
Natural sleep aids, including melatonin, kava, valerian, and other products, are available as dietary supplements. Many sleep aids combine different ingredients and dosages in a pill, liquid, or chewable form.
For most dietary supplements, there is limited research documenting their benefits and risks. For this reason, these products are generally not recommended by the American Academy of Sleep Medicine for insufficient sleep.
It is impossible to choose the best sleep medication for all situations. When a sleep aid is needed, the optimal choice depends on a person’s circumstances including the nature of their sleep problems, overall health and coexisting conditions, other medications they are taking, and the cost and availability of different medications.
Given the multitude of factors that can inform this decision, it is best to talk with a doctor before taking any sleep aid, including those that are sold over-the-counter or as a dietary supplement.
Sleep medications are frequently prescribed to treat insomnia or insomnia-like symptoms. Insomnia is the inability to fall asleep or stay asleep even when there is an opportunity to do so, and it frequently interferes with how a person thinks, feels, or acts the next day.
Drugs designed to make a person drowsy or stay sleeping throughout the night, such as hypnotic-sedative medications, are typically intended to allow people with symptoms of insomnia to sleep better.
Some sleep medications, including melatonin, may also be used to treat circadian rhythm sleep disorders, which occur when a person’s internal clock is misaligned with the day-night cycle. People who have jet lag from air travel or shift work disorder from working at night may benefit from melatonin.
Other types of sleep disorders, such as parasomnias or restless leg syndrome, may be treated with other types of drugs that are intended to address the symptoms of those conditions rather than induce sleepiness.
Many sleeping problems can be addressed without any sleep medications at all. In fact, in many cases, non-medical approaches are preferred as a first treatment, with medications only being used if sleep problems persist. This is especially true for older adults and people with coexisting health conditions who may be more likely to have adverse reactions to sleep medications.
A well-established alternative to sleep medications is cognitive behavioral therapy for insomnia (CBT-I). CBT-I helps uncover and reorient negative thinking about sleep while encouraging better sleep hygiene.
Improvements to sleep hygiene, including the sleep environment and daily habits, are often helpful in improving the quality and consistency of a person’s sleep. Sleep hygiene changes may include setting a standard sleep schedule, reducing alcohol and caffeine intake, and optimizing the bedroom environment to eliminate sleep disruptions. A regular nightly routine to get ready for bed, including steps to help relax and unwind, are often helpful for people who struggle to fall asleep.
Depending on a person’s situation, these non-medical approaches may be used along with sleep medications as a form of combination therapy.
The potential benefits of sleep medications are improved sleep duration, better ability to sleep through the night, and a more stable sleep schedule. Improving sleep can reduce daytime sleepiness. Sleep aids may help reset sleep patterns to enable healthier habits.
The possible downsides of sleep aids vary based on the specific medication and the person taking them. Some of the risks of taking sleep aids include:
Sleeping pills are most likely to be effective when used under the guidance of a medical professional who can recommend specific drugs as well as the proper dosage and time to take them.
Healthy adults can often take sleep aids for a short-term period with few negative effects, but this depends significantly on the type of sleep aid and their individual health.
Because of an elevated potential for side effects, the following groups of people should generally not take any type of sleeping pills without first consulting with their doctor:
No matter what type of sleep medication you take, there are several precautions that help ensure that you take your sleep aid safely.
Step 1:
Consult with your doctor about your sleep problems and which sleep aid offers the most potential benefits and fewest downsides. It’s important to consult with a doctor to determine the source of the problem, if possible. Many other factors including depression, anxiety, thyroid disorder, peri-menopause, obstructive sleep apnea, asthma, heart failure, and other medications can cause problems with sleep.
Step 2:
Remember that these drugs are generally not intended for long-term use. The goal is to help improve your sleep in the short-term while allowing you to develop healthy sleep hygiene that can pay off over the long-term.
Step 3:
Double-check with your doctor or pharmacist about whether the dosage is right for you. For example, women eliminate sleep aids differently, so the FDA has recommended a lower dose of some sleep medications because of numerous reports of excessive next-day grogginess. The dosage should also be calibrated to whether you have problems falling asleep or staying asleep.
Step 4:
Carefully follow all the instructions for taking your sleep medication. This includes only taking the prescribed dose and doing so at the right time to ensure the most help for your sleep and reduce risks of grogginess the next morning.
While this step may seem obvious, a study found widespread improper use of common prescription sleep medication. It was discovered that many people took too high of a dose, took the pill too late at night, and/or continued taking the drug for longer than intended.
Step 5:
As you take the sleep medication, be on the lookout for warning signs of adverse effects and talk to your doctor if you detect them. Examples of these warning signs include:
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